Contamination of medicinal plants with heavy metals and its allowable level

Document Type : Scientific Views

Authors

1 Researcher of Research Institute of Forests and Rangelands

2 Assistant Prof., Research of Research Institute of Forests and Rangelands, P. O. Box 13185-116,

3 Assistant Prof., Research of Research Institute of Forests and Rangelands

Abstract

-Contamination of soils and waters, and consequently plants, with heavy metals is one of the most important environmental issues. If these plants are medicinal plants, the excess amounts of metal ions threaten human health. Numerous reports indicate the contamination of medicinal and aromatic plants and the high potential of these plants in the absorption of heavy metals, their transfer to the food sector and even its entry into herbal medicines. Contamination of medicinal plants and by-products with heavy metals during the growing season, processing of crops or intentional addition of plant products in traditional medicine of India and China by claiming their healing properties. Since the use of medicinal plants in the treatment of many diseases is considered and it is mainly believed that medicinal plants do not have side effects due to their natural origin, so medicinal plants and their products should be free of heavy toxic metals. Therefore, the World Health Organization (WHO) has emphasized that plants with medicinal and therapeutic functions must be tested to confirm the presence of heavy metals. Since it is not possible to completely remove heavy metals in plant products, it is necessary to define a permissible limit of heavy and toxic metals. In this paper, the reaction of medicinal plants to heavy metals, the allowable limit of heavy metals according to the standards of the World Health Organization and pharmacies of different countries, and the tolerable weekly consumption of heavy metals are presented.

Keywords


Abdullahi, M.S., Abubakar, U.S., Safiyanu, I., Hadiza, R.J., Sa’adatu, A.U. and Jamila G.A., 2019. Phytochemical analysis and accumulation of heavy metals in some common medicinal plants. Journal of Pharmacognosy and Phytochemistry, 8(3): 2692-2696.
Alloway, B.J., 2011. Heavy Metals in Soil, Third edition. John Wiley and Sons, Inc., New York, USA.
Arpadjan, S., Celik, G., Taskesen, S. and Giicer, S., 2008. Arsenic, cadmium and lead in medicinal herbs and their fractionation. Food and Chemical Toxicology, 46: 2871-2875.
Baye, H. and Hymete, A., 2010. Lead and cadmium accumulation in medicinal plants collected from environmentally different sites. B Environ. Contam. Tox., 84(2): 197–201.
Bhargava, A., Shukla, S., Srivastava, J., Singh, N. and Ohri, D., 2008. ChcnupuJiunr A prospective plant for phytoextraclion Ada Pliysinlogim, I'luntiinini, 10: 111-120.
Cairrao, E., Pereira, M.J., Pastorinho, M.R., Morgado, F., Scares, A.M.V.M. and Gui-Ihermino, L., 2007. Fucus spp. as a mercury contamination bioindicator in coastal areas (Northwestern Portugal). Bulletin of Environmental Contamination and Toxicology, 79: 388-395.
Carrubba, A. and Scalenghe, R., 2012. The scent of mare Nostrum: medicinal and aromatic plants in Mediterranean soils. J. Sci. Food Agric., 92: 1150–1170.
Chaiyarat, R., Suebsima, R., Putwattana, N., Kruatrachue, M. and Pokethitiyook, P., 2011. Effects of soil amendments on growth and metal uptake by Ocimum gratissimum. Water, Air, & Soil Pollution, 214: 383-392.
Chan, K., 2003. Some aspects of toxic contaminants in herbal medicines. Oic-mosphereSI, 1361-1371.
Choudhury, R.P., Kumar, A. and Garg, A.N., 2006. Analysis of Indian mint (Mentha xpicata) for essential, trace and toxic elements and its antioxidant behavior. Journal of Pharmaceutical and Biomedical Analysis, 41: 825-832.
Chizzola, R. and Lukas, B., 2005. Variability of the cadmium content in Hypericum species collected in Eastern Austria. Water, Air, and Soil Pollution, 170: 331-343.
Chizzola, R. and Mitteregger, U.S., 2005. Cadmium and zinc interactions in trace element accumulation in chamomile. Journal of Plant Nutrition, 28: 1383-1396.
Chizzola, R., 2005. Cadmium and micronutrient accumulation in yarrow. Phyton, 45: 159-171.
Chizzola, R., 2001. Micronutrient composition of Pa/iuver somnilemni I., grown under low cadmium stress condition. Journal of Plant Nutrition, 24: 1663-1677.
Dietrich’s, N., Feiter, U. and Wynberg, R., 2006. Production of traditional medicines: technologies, standards and regulatory issues. Commercializing Medicinal Plants: A southern African Guide. Sun Press, Stellenbosch, pp. 155–166.
Denholm, J., 2010. Complementary medicine and heavy metal toxicity in Australia. WebmedCentral 1: 1–6.
. Doroszewska, T. and Berbe£, A., 2004. Variation for cadmium uptake among Nicoti-ana species. Genetic Resources and Crop Evolution, 51: 323-333.
Dwivedi SK. and Dey S., 2002. Medicinal herbs: A potential source of toxic metal exposure for man and animals in India. Arch Environ Health, 57(3): 229-231.
Ebrahim, A.M., Eltayeb, M.H., Khalid, H., Mohamed, H., Abdalla, W., Grill, P. and Michalke, B., 2012. Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. J. Nat. Med., 66(4): 671–679.
EC (629/2008), Commission Regulation 629/2008 (2 July 2008) amending Regulation (EC) No 1881/2006 setting maximum levels for certain contami-nants in foodstuffs. Official Journal of the -European Union 2008. (LI73). 6-4.
Falcó, G., Gdmez-Catalan, J., Llobet, J.M. and Domingo, J.L., 2003. Contribution of medicinal plants to the dietary' intake of various toxic elements in Catalonia. Spam. Trace Elements Electrolytes, 20: 120-124.
Falcó, G., Llobet, J.M., Zareba, S., Krzysiak, K. and Domingo, J.L., 2005. Risk assessment of trace elements intake through natural remedies in Poland. Trace Elements Electrolytes, 22: 222-226.
Fijalek, Z., Soltyk, K., Lozak, A., Kominek, A. and Ostapczuk, P., 2003. Determination of some micro- and macroelements in preparations made from peppermint and nettle leaves. Phurmuzie, 58:480-482.
Garg, C., Khan, S.A., Ansari, S.H. and Garg, M., 2010. Efficacy and safety studies of Foeniculum vulgare through evaluation of toxicological and standardisation parameters. International Journal of Pharmacy and Pharmaceutical Sciences, 2: 43-45.
Gasser, U., Klier, B., Kuhn, A.V. and Steinhoff, B., 2009. Current findings on the heavy metal content in herbal drugs. Pharmeuropa Scientific Notes, 1: 37-50.
Grant, C.A. and Bailey, L.D., 1997. Effects of phosphorous and zinc fertilizer management on cadmium accumulation in flaxseed. Journal of Science and Food Agriculture, 73: 307-314.
Grejtovsky, A., Markusova, K. and Eliasova, A., 2006. The response of chamomile (Matricaria chamomilla L.) plants to soil zinc supply. Plant, Soil and Envi-ronment, 52: 1-7.
Guedon, D., Brum, M., Bizet, D., Bizo, S, Bourny, E., Compagnon, P.A., Kergosien, H., Quintelas, L.G., Respau, J., Saperas, O., Seigneuret, J.M., Taoubi, K. and Urizzi, P., 2007. Impurities in herbal substances, herbal preparations and herbal medicinal products. IV. Heavy (toxic) metals. Pharma Pratiques 18. 231 -268 and Natural Product Communications 3: 2107-2122.
Han, XL., Zhang, XB., Guo, LP., Huang, LQ., Li, MJ., Liu, XH., Sun, YZ. and I.v, JR., 2008. Statistical analysis of residues of heavy metals in Chinese crude drugs. Zhongguo Zhongyao Zazhi, 33: 2041 -2048.
Harris, E.S.J., Cao, S., Littlefield, B.A., Craycroft, J,A., Scholten, R., Kaptchuk, T., Fu, Y., Wang, W., Liu, Y., Chen, H., Zhao, Z., Clardy, J., Woolf, A.D. and Eisenberg, D.M., 2011. Heavy metal and pesticide content in commonly prescribed individual raw Chinese herbal medicines. The Science of the Total Environment, 409: 4297-4305.
Herbal Drugs Monograph 1433. Pharmeuropea, 2008, 20, 302-303.
Kabelitz, L., 1998. Heavy metals in herbal drugs. European Journal of Herbal Medicine, 4: 25-33.
Karahan, F., Ozyigit, I.I., Saracoglu, I.A., Yalcin, I.E., Hocaoglu Ozyigit, A. and Ahmet Ilcim, A., 2020. Heavy Metal Levels and Mineral Nutrient Status in Region Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean of Turkey, Biological Trace Element Research, 197: 316–329.
Kohzadi, S., Shahmoradi, B., Ghaderi, E., Loqmani, H. and Maleki, A., 2019. Concentration, Source, and Potential Human Health Risk of Heavy Metals in the Commonly Consumed Medicinal Plants, Biological Trace Element Research, 187(1):41-50.
Kosalec, I., Cvek J., Tomić, S., 2009. Contaminants of medicinal plants herbs and herbal products. Archives of Industrial and Hygiene Toxicology, 60, 485-501..
Li, Q., Cai, S., Mo, C., Chu, B., Peng, L. and Yang, F., 2010. Toxic effects of heavy metals and their accumulation in vegetables grown in a saline soil. Ecotoxicol. Environ. Saf., 73(1): 84–88.
Lugon-Moulin, N., Martin, F., Krauss, MR., Ramey, PB. and Rossi, L., 2006. Cadmium concentration in tobacco (Nicotiana labacum L.) from different countries and its relationship with other elements. Chemosphere, 63: 1074-1086.
Marschner, H., 1995. Mineral Nutrition ol Higher Plants (2nd Edition). Academic Press, Harcoun Press and Co., London, 889p.
Martena, M.J., Widen, J.C.A., Rictjcns, I.M.C.M., Klcrx Y.V.M.M., Croot H.N. and Konings, E.J.M., 2010. Monitoring of mercury, arsenic, and lead in tra ditionat Asian herbal preparations on the Dutch market and estimation of associated risks. Food Additives and Contamination, 27: 190-205.
Moraghan, J.T., 1993. Accumulation of cadmium and selected elements in flax seed grown on a calcareous soil. Plant and Soil, 150: 61-68.
Österhas, A.H. and Greger, M., 2003. Accumulation of, and interactions between, calcium and heavy metals in wood and bark of Picea abies. Journal of Plant Nutrition and Soil Science, 166: 246-253.
Pinto, A.P., Mota, A.M., de Varennes, A. and Pinto, F.C., 2004. Influence of organic matter on the uptake of cadmium, zinc, copper and iron by sorghum plants. The Science of the Total Environment, 326: 239-247.
Pluquct, E., Filipinski, M. and Gruppc, M., 1990. Zur Cadmiumauthahnic von Kulturpflanzcn aus gcogcn und anthropogcn mil Cadmium angcrcichcncn Boden. Zeitschrifl fiir Kiilinriethnik tmtJ Landcntv. Ickliing, 31:105-111.
Radanovic, D., Antic-Mladenovic, S. and Jakovlevic, M., 2002. Influence of some soil characteristics on heavy metal content in Hypericum perforatum L. and Achillea millefolium L. Ada Horticulture, 576: 295-301
Raman, P., Patino, L. and Nair, M.G., 2004. Evaluation of metal and microbial contamination in botanical supplements. Journal of Agricultural and Food Chemistry, 52: 7822-7827.
Ramos, I., Esteban, E., Lucena, J.J. and Garate, A., 2002. Cadmium uptake and sub-cellular distribution in plants oiLactuca sp. Cd-Mn interaction. Plant Science, 162: 761-767.
Rehman, Kh., Hamayun, M., Afzal Khan, S., Amjad Iqbal, A. and Hussain, A., 2019. Heavy Metal Analysis of Locally Available Anticancer Medicinal Plants. Biosciences Biotechnology Research Asia, 16(1): 105-111.
Reimann, C., Roller, F., Frengstad, B., Kashulina, G., Niskavaara, H. and Englmaier, P., 2001. Comparison of the element composition in several plant species and their substrate from a 1 500 000-km2 area in Northern Europe. The Science of the Total Environment, 278: 87-112.
Roosens, N., Verbruggen, N., Meerts, P., Ximénez-Embum, P. and Smith, J.A.C., 2003. Natural variation in cadmium tolerance and its relationship to metal hyperaccumulation for seven populations of Thlaspi caerulescens from Western Europe. Plant, Cell and Environment, 26: 1657-1672.
Salamon, I. and Plackova, A., 2007. Environmental risks associated with the production and collection of chamomile flowers. Ada Horticulture, 749: 211-215.
Salamon, I., Králóvá, K. and Masarovićová, E., 2007a. Accumulation of cadmium in chamomile plants cultivated in Eastern Slovakia regions. Acta Horlicullurae, 749: 217-222.
Sarma, H., Deka, S., Deka, H. and Saikia, R.R., 2011. Accumulation of heavy metals in selected medicinal plants. Reviews of environmental contamination and toxicology. Springer, pp. 63-86.
Schilcher, H., 1994. Zur Frage der SchadstofTe in Arznei- und GewQrzpflanzen sowie dcren Zubcrcitungen. Ubersicht und aktuelle rechtliche Bewertung von Rucksta'nden. Herba Germanica, 2: 1-18.
Schilcher, H. and Peters, H., 1990. Empfehlungen von Richt- und Grenzwerten fur den maximalen Blei- und Cadmiumgehalt von Arzneidrogen und daraus her-gestellter phannazeutischer Zubereitungen. Pharamzeutische Industrie, 52: 916-921
Schilcher, H., Peters, H. and Wong, H., 1987. Oestizide und Schwermetalle in Arzneipflanzen und Arzneipflanzenzubereitungen. Pharamzeutische Industrie, 49: 203-211.
Schneider, E., Pank, F., Koball, G., Pollys, de Garcia, E., Dehe, M. and Bliithner, W.D., 2002. Einfluss von Genotyp und Umwelt auf die Cadmiumaufhahme des Johanniskrautes (Hypericum perforatuin L.). Zeitschrift fur Arznei und Gewiirzpflanzen, 7: 329-335.
Schneider, M. and Marquard, R., 1996. Aufhahme und Akkumulation von Cadmium und weiterer Schwermetalle bei Hypericum perforatum L. und Linum usitatissimum L. Zeitschrift fur Arznei und GewurzpfJanzen, 1: 111-116.
Shahid, M., Dumat, C., Khalid, S., Schreck, E., Xiong, T. and Niazi, N.K., 2017. foliar heavy metal uptake, toxicity and detoxification in plants: a comparison of foliar and root metal uptake. J. Hazard Mater., 325: 36–58.
Steenkamp, V, Stewart, M.J., Curowska, E. and Zuckerman, M., 2002. A severe case of multiple metals poisoning in a child treated with a traditional medicine. Forensic Sci Int, 128(3): 123-126.
Street, R.A., 2012. Heavy metals in medicinal plant products– an African perspective. S Afr. J. Bot., 82: 67–74.
Tschinkel, P.F.S., Melo, E.S.P., Pereira, H.S., Silva, K.R.N., Arakaki, D.G., Lima, N.V., Fernandes, M.R., Leite, L.C.S., Melo, E.S.P., Melnikov, P., Espindola, P.R., de Souza, I.D., Nascimento, V.A., Júnior, J.L.R., Geronimo, A.C.R., dos Reis, F.J.M. and Nascimento, V.A., 2020. The Hazardous Level of Heavy Metals in Different Medicinal Plants and Their Decoctions in Water: A Public Health Problem in Brazil, BioMed Research International, Volume 2020, Article ID 1465051, 11 pages.
Tlustoš, P., Szakova, J., Vyslouzilova, M., Pavlikova, D., Weger, J. and Jarovska, H., 2007. Variation in the uptake of arsenic, cadmium, lead, and zinc by different species of willows Salix spp. grown in contaminated soils. Central European Journal of Biology, 2: 254-275.
Walker, D.J. and Bernal, M.P., 2004. The effects of copper and lead on growth and zinc accumulation of Thlatpi caerulescens J. and C. Presl. Implications t'oi phytoremediation of contaminated soils. Water, Air and Soil Pollution, 151: 361-372.
Wang, Zh., Wang, Ho., Wang, Ha., Li, Q. and Li, Y., 2019. Heavy metal pollution and potential health risks of commercially available Chinese herbal medicines. Science of the Total Environment, 653: 748–757. 
WHO (World Health Organization), 1999. Monographs on Selected Medicinal Plants (Vol. 1), Geneva, Switzerland.
WHO, 1998. Quality control methods for medicinal plant materials, Geneva, 115p.                  
WHO, 2000. General guidelines for methodologies on research and evaluation of traditional medicine, Geneva, 71p.
WHO, 2005. National policy on traditional medicine and regulations of herbal medicines, Geneva, 156p.
WHO, 2007. WHO Guidelines for assessing quality of herbal medicines with reference to contaminants and residues. WHO Publishers, Geneva, 105p.
Zheljazkov, V.D. and Warman, P.R., 2004. Application of high-Cu compost to dill and peppermint. Journal of Agricultural and Food Chemistry, 52: 2615-2622.
Zheljazkov, V.D., Jeliazkova, E.A. and Craker, L.E., 1999. Heavy metal uptake by mint. Acta Horlicullurae, 500: 111-117.
Zheljazkov, V.D., Craker, L.E. and Xing, B., 2006. Effects of Cd, Pb, and Cu on growth and essential oil contents in dill, peppermint, and basil. Environ. Exp. Bot., 58(1): 9–16.
Zheljazkov, V.D., Craker, L.E., Xing, B., Nielsen, N.E. and Wilcox, A., 2008a. Aromatic plant production on metal contaminated soils. Sci. Total Environ., 395(2): 51–62.
Zheljazkov, V.D., Jeliazkova, E.A., Kovacheva, N. and Dzhurmanski, A., 2008b. Metal uptake by medicinal plant species grown in soils contaminated by a smelter. Environ. Exp. Bot., 64: 207–216.
Zheljazkov, V.D. and Nikolov, S., 1996. Accumulation of Cd, Pb. Cu, Mn. and Zn by Silybum murianum L. Ada Horlicultiirae, 426: 297-308.
Zheljazkov, V.D. and Nielsen, N.E., 1996. Growing clary sage (Stihia sckin'u L.) in heavy metal-polluted areas. Acta Horliculturtie, 426: 309-328.
 
 
.