Can medicines with antiviral activities be made from medicinal plants?

Document Type : Scientific Views

Author

Prof., Research Institute of Forests and Rangelands, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran


- Aboubakr, H.A., Nauertz, A., Luong, N.T., Agrawal, S., El-Sohaimy, S.A., Youssef, M.M. and Goyal, S.M., 2016. In Vitro Antiviral Activity of Clove and Ginger Aqueous Extracts against Feline Calicivirus, a Surrogate for Human Norovirus. Journal of Food Protection, 79(6):1001-1012.
- Arora,  R.,  Marwah, R.C., Arora, P., Vinod Kaushik,  R. K.S., Goel, R. Kaur, A., Silambarasan, M., Tripathi, R.P. and Bhardwaj, J.R., 2010. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. Evidence-Based Complementary and Alternative Medicine, 2011: 586506.
- Arreola, R., Quintero-Fabián, S.,  Ivette López-Roa, R., Flores-Gutiérrez, E.O.,   Reyes-Grajeda, J.P., Carrera-Quintanar, L. and  Ortuño-Sahagún, D., 2015.  Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds. Journal of Immunology Research, 40:16-30.
- Astani, A., Navid, M.H. and Schnitzler, P., 2014. Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract. Phytotherapy Research, 28(10):1547-1552.
- Astani, A., Reichling, J., Schnitzler, P., 2011. Screening for antiviral activities of isolated compounds from essential oils. Evidence-Based Complementary and Alternative Medicine, 2011: 2536- 2543.
- Badgujar, S.B., Patel, V.V., Bandivdekar, A.H., 2014. Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology. BioMed Research International, 2014: 842674.
- Battistini, R., Rossini. I., Ercolini, C., Goria, M., Callipo, M.R., Maurella, C., Pavoni, E. and Serracca, L., 2019. Antiviral Activity of Essential Oils Against Hepatitis A Virus in Soft Fruits. Food and Environmental Virology, 11(1):90-95.
- Bayan, L., Koulivand, P.H. and Gorji, A., 2014. Garlic: a review of potential therapeutic effects. Avicenna Journal of Phytomedicine, 4(1): 1–14.
- Chang, J.S., Wang, K.C., Yeh, C.F., Shieh, D.E. and Chiang, L.C., 2013. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology, 145(1): 146-151.
- Chiang, L.C., Ng, L.T., Cheng, P.W., Chiang, W. and Lin, C.C., 2005. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and Experimental Pharmacology and Physiology, 32(10):811-816.     
- Cho, A., Roh, Y.S., Uyangaa, E., Park, S., Kim, J.W., Lim, K.H., Kwon, J., Eo, S.K., Lim, C.W. and Kim, B., 2013. Protective effects of red ginseng extract against vaginal herpes simplex virus.  Journal of Ginseng Research, 37(2): 210-218.
- Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H. and Doerr, H.W., 2003. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 361 (9374): 2045-2046.
- Chen, S.G.,  Leu, Y.L., Cheng, M.L.,  Ting, S.C.,  Liu, C.C., Wang, S.D., Yang, C.H., Hung, C.Y., Sakurai, H., Chen, K.H. and  Ho, H.Y., 2017. Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports, 7: 1-16.
-  Dehghani, F.,  Merat, A., Panjehshahin, M.R. and  Handjani, F., 2005. Healing effect of garlic extract on warts and corns. International Journal of Dermatology, 44(7): 612-615
- Feng Yeh, C., Wang, K.C., Chiang, L.C., Shieh, D.E., Yen, M.H. and San Chang, J., 2013. Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology, 148(2): 466-473.
- Flores-Ocelotl, M.R., Rosas-Murrieta, N.H.,  Moreno, D.A., Vallejo-Ruiz, V., Reyes-Leyva, J., Domínguez, F. and Santos-López, G., 2018. Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro. BMC Complementary and Alternative Medicine, 18: 95-99.
- Geuenich, S.,  Goffinet, C.,  Venzke, S., Nolkemper, S., Baumann, I., Peter Plinkert Reichling, J. and   Keppler, O.T.,  2008. Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology, 5(27): 1-16.
- Gilling, D.H., Kitajima, M., Torrey, J.R.  and Bright, K.R., 2014. Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus. Journal of Applied Microbiology, 116(5): 1149-1163.
-  Ganjhu, R.K., Mudgal, P.P., Maity, H., Dowarha, D., Devadiga, S.,  Nag, S. and  Arunkumar, G., 2015. Herbal plants and plant preparations as remedial approach for viral diseases. Virusdisease, 26(4): 225–236.
-  Ghorbani, A. and  Esmaeilizadeh, M., 2017. Pharmacological properties of Salvia officinalis and its components.Journal of Traditional and Complementary Medicine,  7(4): 433-440.
-  Hamidpour, M., Hamidpour, R.,  Hamidpour, S. and Shahlari, M., 2014. Chemistry, Pharmacology, and Medicinal Property of Sage (Salvia) to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer. Journal of Traditional and Complementary Medicine, 4(2): 82–88.
-  Hudson, J. and Vimalanathan, S., 2011. Echinacea- A Source of Potent Antivirals for Respiratory Virus Infections. Pharmaceuticals (Basel), 4(7): 1019-1031.
- Han, H., He, W., Wang, W. and Gao, B., 2011. Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complementary and Alternative Medicine, 11:112-119.
- Hawkins, J., Baker, C., Cherry, L. and Dunne, E., 2019. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary Therapies in Medicine, 42:361-365.
- He, W., Han, H., Wang, W. and Gao, B., 2011. Anti-influenza virus effect of aqueous extracts from dandelion. Virology Journal, 8: 538, 11p.
- Hudson, J.B., 2012. Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. Journal of Biomedicine and Biotechnology, 2012: 769896.
- Jia, Y.Y., Guan, R.F., Wu, Y.H., Yu, X.P., Lin, W.Y., Zhang, Y.Y., Liu, T., Zhao, J., Shi, S.Y. and Zhao, Y., 2014. Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. Molecular Medicine Reports, 9(4):1381-1387.
- Khan, H.M., Raza, S.M., Anjum, A.A. and Ali, M.A., 2019. Antiviral, embryo toxic and cytotoxic activities of Astragalus membranaceus root extracts. Pakistan Journal of Pharmaceutical Sciences, 32(1):137-142.
- Kinoshita, E., Hayashi, K., Katayama, H., Hayashi, T. and Obata, A., 2012. Anti-influenza virus effects of elderberry juice and its fractions. Bioscience, Biotechnology, and Biochemistry, 76(9): 1633-1638.
- Kyungtaek, I., Jisu, K. and Hyeyoung, Min., 2016. Ginseng, the natural effectual antiviral: Protective effects of Korean Red Ginseng against viral infection. Journal of Ginseng Research 40(4): 309–314.
-Kallon, S.,  Li, X., Ji, J.,  Chen, C.,  Xi, Q., Chang, S., Xue, C., Ma, J., Xie, Q. and  Zhang, Y., 2013. Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo. Journal of Animal Science and Biotechnology, 4(1): 22, 11p.
-  Khwaza, V., Oyedeji, O.O. and Aderibigbe,B.A., 2018. Antiviral Activities of Oleanolic Acid and Its Analogues. Molecules. 23(9): E2300.
-  Lee, H.S., Ka, P.K.,  Kim, Y. and Seol, G.H., 2015.   Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-κB Activation. Korean Journal of Physiology and Pharmacology, 19(2): 183–189.
-  Lee, J.S.,  Ko, E.J.,  Hwang, H.S., Lee, Y.N., Kwon, Y.M., Kim, M.C. and  Kang, S.M., 2014. Antiviral activity of ginseng extract against respiratory syncytial virus infection. International Journal of Molecular Medicine, 34(1): 183–190.
- Li, Y.X., Liu, Y.B., Ma, A.Q., WangY.B.M. and  Sun, Z.L., 2017. In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L. Food Science and Biotechnology, 26(6): 1675–1683.
-  Lipke, M.M., 2006. An Armamentarium of Wart Treatments. Clinical Medicine & Research, 4(4): 273–293.
- McKay, D.L. and Blumberg, J.B., 2006. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy Research, 20(8):619-633.
- Mondal, S., Varma, S., Bamola, V.D., Naik, S.N., Mirdha, B.R., Padhi, M.M., Mehta, N. and Mahapatra, S.C., 2011. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. Journal of Ethnopharmacology, 136(3): 452-456.
- Nolkemper, S.1., Reichling, J., Stintzing, F.C., Carle, R. and Schnitzler, P., 2006. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta Medica, 72(15):1378-1382.
-  Pourghanbari, G.,  Nili, H., MoattariA., Mohammadi, A. and  Iraji, A., 2016. Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2). Virusdisease. 27(2): 170–178.
- Wang, L., Yang, R., Yuan, B., Liu, Y. and  Liu, C., 2015. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharmaceutica Sinica B, 5(4): 310–315.
- Oliveira, J.R.,  Camargo, S.E.A. and  Oliveira, L.D., 2019. Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent. Journal of Biomedical Science, 26: 5, 22p.
- Pilau, M.R., Alves, S.H., Weiblen, R., Arenhart, S., Cueto, A.P. and Lovato, L.T., 2011Antiviral activity of the Lippia graveolens (Mexican oregano) essential oil and its main compound carvacrol against human and animal viruses. Brazilian Journal of Microbiology, 42(4):1616-1624.
- Pilau, M.R., Alves, S.H., Weiblen, R., Arenhart, S., Cueto, A.P. and Lovato, L.T., 2011. Brazilian Journal of Microbiology, 42(4): 1616–1624.
- Rasool, A., Khan, M.U., Ali, M.A., Anjum, A.A., Ahmed, I., Aslam, A., Mustafa, G., Masood, S., Ali, M.A. and Nawaz, M., 2017. Anti-avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos. Pakistan journal of pharmaceutical sciences, 30(4):1341-1344.
- Santoyo, S., Jaime, L., García-Risco, M.R., Ruiz-Rodríguez, A. Reglero, G., 2014. Antiviral Properties of Supercritical CO2 Extracts from Oregano and Sage. International Journal of Food Properties, 17(5): 1150-1161 
- Schnitzler, P., Schuhmacher, A., Astani, A. and Reichling, J., 2008. Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine. 15(9):734-40.
- Sharifi-Rad, J., Salehi, B., Schnitzler, P., Ayatollahi, S.A., Kobarfard, F., Fathi, M., Eisazadeh, M. and Sharifi-Rad, M., 2017. Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. Cellular and Molecular Biology,  63(8): 42-47.
- Shi,  L., Yin, F., Xin, X., Mao,  S.,  Hu,  P.,  Zhao,  C. and  Sun, X., 2014. Astragalus Polysaccharide Protects Astrocytes from Being Infected by HSV-1 through TLR3/NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine, 2014: 285356, 6p.
- Smidling, D., Mitic-Culafic, D., Vukovic-Gacic, B., Simic, D. and Knezevic-Vukcevic, J., 2008. Evaluation of antiviral activity of fractionated extracts of sage Salvia officinalis L. (Lamiaceae). Archives of Biological Sciences, 60(3): 421-429.
- Sun, Y. and Yang, J., 2004. Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1. Di Yi Jun Yi Da Xue Xue Bao, 24(1):57-58 (in Chinese).
- Schaefer, T.j., Panda, P.K. and Wolford, R.W., 2019. Dengue Fever. https://www.ncbi.nlm.nih.gov/books/NBK430732/
- WangL., YangR., YuanB., Liu, Y. and Liu, C., 2015. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharmaceutica Sinica B, 5(4): 310–315.